Condition: Alzheimer Disease · Frontotemporal Dementia · Parkinson Disease · Sponsor: Universidad Autonoma de San Luis Potosí
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 \[TDP43\]) in skin biopsies of patients with a neurodegenerative disease like Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus. The main question it aims to answer is: * Is there a specific pattern of aggregation of proteinopathies in skin biopsies in each neurodegenerative disease in comparison to healthy control subjects? Skin biopsies will be analyzed using immunohistochemistry and immunofluorescence for detection of alpha-synuclein, amyloid-beta, phosphorylated tau and TAR DNA binding protein 43, and the aggregation patterns will be compared between patients with a neurodegenerative disease vs patient with normal pressure hydrocephalus vs healthy control subjects.
This description comes directly from the study's public registry record.
Ildefonso Rodríguez-Leyva, MD PhD · +52 444 834 2739 · ilrole@yahoo.com.mx
Cristina Monzón Tapia, MD · a267473@alumnos.uaslp.mx
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| Hospital Central Dr. Ignacio Morones Prieto | San Luis Potosí City, Mexico | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06528964