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Study identifier: NCT06528691 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

Condition: High Grade Glioma · CNS Tumor  ·  Sponsor: St. Jude Children's Research Hospital

PhasePhase 2
Planned participants52
Who can joinAll sexes, N/A to 3 Years
Healthy volunteersNo

About this study

This clinical trial tests how well entrectinib works to treat patients less than 3 years of age with NTRK 1/2/3 or ROS1 fused, high grade glioma or other central nervous system (CNS) tumors.

This description comes directly from the study's public registry record.

Talk to the study team

Tabatha E. Doyle, RN  ·  901-595-2544  ·  tabatha.doyle@stjude.org

Daniel Moreira, MD, MEd  ·  901-585-1911  ·  daniel.moreira@stjude.org

Always discuss trial participation with your own doctor first.

Locations (6)

St. Jude Children's Research HospitalMemphis, Tennessee, United StatesRecruiting
Hospital de Câncer de BarretosBarretos, São Paulo, BrazilRecruiting
GRAACC Hospital (Grupo de Apoio ao Adolescente e à Criança com Câncer)São Paulo, BrazilRecruiting
Hospital Santa MarcelinaSão Paulo, BrazilRecruiting
King Hussein Cancer CenterAmman, JordanRecruiting
Instituto Nacional de Enfermedades NeoplásicasLima, PeruRecruiting

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Source record: clinicaltrials.gov/study/NCT06528691