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Study identifier: NCT06528431 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Design and Evaluation of an Individualized Biodrug Tapering Strategy Based on Biodrug Dosage: the MONITORA Study

Condition: Arthritis, Rheumatoid  ·  Sponsor: Centre Hospitalier Universitaire de Saint Etienne

PhasePhase 4
Planned participants180
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Rheumatoid arthritis (RA) is the most common inflammatory joint disorder. Since twenty year and the use of synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and biological (b)DMARD, remission can be reached. When remission is obtained, the physician has no recommendations for managing a step-down, and future guidelines will be useful to assist the clinician. Recent data suggest that tapering is feasible, but with high risk of flares. Flares are less frequent when bDMARD blood concentration is high. But, the optimal adalimumab concentration to keep before a step of tapering no targeting personal is unknown.

This description comes directly from the study's public registry record.

Talk to the study team

Hubert MAROTTE, MD PhD  ·  (0)4 77 12 76 49  ·  hubert.marotte@chu-st-etienne.fr

Madjid AKROUR  ·  (0)4 77 12 78 37  ·  madjid.akrour@chu-st-etienne.fr

Always discuss trial participation with your own doctor first.

Locations (8)

Infirmerie ProtestanteCaluire-et-Cuire, FranceRecruiting
Chd VendeeLa Roche-sur-Yon, FranceRecruiting
Hopital PhilibertLomme, FranceRecruiting
Chu MontpellierMontpellier, FranceRecruiting
Ap-Hp Pitie SalpetriereParis, FranceRecruiting
Chu ReimsReims, FranceNot Yet Recruiting
Chu Saint EtienneSaint-Etienne, FranceRecruiting
Chru ToursTours, FranceNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06528431