Condition: Heart Failure With Reduced Ejection Fraction · Sponsor: University of Colorado, Denver
An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF). When used in combination at recommended doses, patients often experience significant improvements in cardiac function, quality of life, and survival.1,2 However, GDMT underuse occurs for the vast majority of patients with HFrEF. Two recent trials demonstrated improved GDMT prescribing during a clinic visit, each using automated delivery of a patient-centered decision support tool to promote a proactive and holistic approach to prescribing: EPIC-HF (NCT03334188) tested a brief video and checklist document sent to patients just prior to a clinic visit encouraging them to work with their clinicians to make at least 1 positive change to their GDMT; PROMPT-HF (NCT05433220) tested tailored electronic health record (EHR) alerts for GDMT intensification delivered to clinicians during clinic visits. The current I-I-CAPTAIN-HF study aims to broadly implement and test the EPIC-HF patient-facing and PROMPT-HF clinician-facing tools for HFrEF medication intensification at 5 health systems around the country through a pragmatic cluster-randomized implementation-effectiveness trial. This will occur through an initial phase of adaptation of the 2 tools at each health system. Once ready, the 2 tools will be tested using a 2x2 randomization at the clinician-level. In parallel, formal assessment of the implementation of EPIC-HF a…
This description comes directly from the study's public registry record.
Larry A Allen, MD, MHS · 303-724-4713 · larry.allen@cuanschutz.edu
Daniel D Matlock, MD, MPH · 303-724-9941 · daniel.matlock@cuanschutz.edu
Always discuss trial participation with your own doctor first.
| Sutter Health | Walnut Creek, California, United States | Recruiting |
| University of Colorado | Aurora, Colorado, United States | Recruiting |
| Yale University | New Haven, Connecticut, United States | Recruiting |
| Northwestern University | Chicago, Illinois, United States | Recruiting |
| University of Utah | Salt Lake City, Utah, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06526988