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Study identifier: NCT06525740 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery

Condition: Malignant Female Reproductive System Neoplasm  ·  Sponsor: Mayo Clinic

PhasePhase 4
Planned participants140
Who can joinFemale, N/A to no upper limit
Healthy volunteersNo

About this study

This phase IV trial compares methadone versus hydromorphone given in the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord (intrathecal) for postoperative pain relief in patients with gynecologic cancer undergo surgery. Methadone binds to opioid receptors in the central nervous system and is a long-acting opioid pain medication. Intrathecal hydromorphone works by changing the way the brain and nervous system respond to pain and is similar to an epidural. This trial may help researchers determine if methadone works as well as intrathecal hydromorphone for pain relief after surgery in patients with gynecologic cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Referral Office  ·  855-776-0015  ·  mayocliniccancerstudies@mayo.edu

Karen Ishitani, R.N.  ·  507-538-5355  ·  Ishitani.Karen@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Mayo Clinic in RochesterRochester, Minnesota, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06525740