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Study identifier: NCT06525220 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Condition: Head and Neck Squamous Cell Carcinoma  ·  Sponsor: Merus B.V.

PhasePhase 3
Planned participants700
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 3 randomized, open-label study to evaluate the efficacy and safety of petosemtamab plus pembrolizumab vs pembrolizumab in first-line treatment of recurrent or metastatic PD-L1+ head and neck squamous cell carcinoma.

This description comes directly from the study's public registry record.

Talk to the study team

Head of Clinical Operations  ·  +1 617 401 4499  ·  USenquiries@merus.nl

Always discuss trial participation with your own doctor first.

Locations (205)

Site 164Mobile, Alabama, United StatesRecruiting
Site 36La Jolla, California, United StatesRecruiting
Site 27Los Angeles, California, United StatesRecruiting
Site 16Palo Alto, California, United StatesRecruiting
Site 19Newark, Delaware, United StatesRecruiting
Site 108Washington D.C., District of Columbia, United StatesRecruiting
Site 14Fort Myers, Florida, United StatesRecruiting
Site 48Orlando, Florida, United StatesWithdrawn
Site 8Orlando, Florida, United StatesRecruiting
Site 21St. Petersburg, Florida, United StatesRecruiting
Site 20West Palm Beach, Florida, United StatesRecruiting
Site 171Atlanta, Georgia, United StatesRecruiting

+ 193 more locations — full list on the registry record.

Follow this study

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Source record: clinicaltrials.gov/study/NCT06525220