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Study identifier: NCT06524570 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Treatment of Cancer With Immune Checkpoint Inhibition Therapy Boosted by High Intensity Focused Ultrasound Histotripsy

Condition: Cancer · Metastatic Cancer  ·  Sponsor: UMC Utrecht

PhasePhase 1
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase 1 clinical trial aims to evaluate the safety, tolerability and feasibility of combination treatment of High Intensity Focused Ultrasound Histotripsy (HIFU-HT) and immune checkpoint inhibitors (ICI) in adult patients with metastatic or unresectable cancer that have progressive disease after regular treatment. Patients will undergo one single session of HIFU-HT during treatment with ipilimumab and nivolumab. Safety, tolerability and feasibility endpoints will be studied as well as radiologic, immunologic and clinical response.

This description comes directly from the study's public registry record.

Talk to the study team

Karijn P.M. Suijkerbuijk, Prof.  ·  +31655234706  ·  k.suijkerbuijk@umcutrecht.nl

Emma J. van Dijk, M.D.  ·  e.j.vandijk-9@umcutrecht.nl

Always discuss trial participation with your own doctor first.

Locations (1)

University Medical Center UtrechtUtrecht, Utrecht, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06524570