Condition: Liver Diseases · Hepatocellular Carcinoma · Hepatocarcinoma · Sponsor: University Hospital Muenster
The aim of this observational study is to predict the short- and long-term development of acute severe disease events, de novo hepatocarcinoma (HCC) and mortality in patients with advanced chronic liver disease using the M10S20 (Liver stiffness and Model for End-Stage Liver Disease Score \[MELD\] combined) and PLEASE (Platelet, Etiology, Age, Sex und Elastography) scores, as well as the validation of the cost-effectiveness of the algorithm. Patients in this study are randomly divided into two groups: * Control group: patients are examined according to the current clinical standard protocol (biannual follow-up). * Stratified surveillance program: * High-risk patients will receive an appointment for a hospital visit every 3 months. * Low-risk patients could receive an appointment in one year. When necessary, if decompensation develops or HCC occurs, patients could be followed-up more frequently.
This description comes directly from the study's public registry record.
Jonel Trebicka, Prof. Dr. med. · +49 02518359689 · jonel.trebicka@ukmuenster.de
Josune Cabello Calleja, PhD · +34 688689194 · josune.cabello@ukmuenster.de
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| University Hospital Muenster | Münster, North Rhine-Westphalia, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06523608