Condition: Neuroendocrine Neoplasm · Neuroendocrine Neoplasm of Gastrointestinal Tract · Neuroendocrine Neoplasm of Lung · Sponsor: Universidad Nacional Autonoma de Mexico
Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs. Their clinical behavior is quite variable, encompassing both benign lesions and aggressive tumors that invade surrounding and/or distant structures. NENs may also cause serious morbidity due to hormone oversecretion. NENs are among the most frequently inherited human tumors, presenting either isolated or as part of syndromes in which a single patient or family develops multiple tumors. There are also non-inherited changes in the genetic information of the tumor cells that are potential targets for treatment. Both inherited and non-inherited DNA defects can be identified using modern routine genetic tests which, unfortunately, are not widely available in Mexico. This project seeks to uncover the genetic defects causing NENs in a large cohort of Mexican patients, using three different methods for genetic testing. Adult individuals with various types of NENs from two reference hospitals in Mexico City will be invited to participate. After completing informed consent, blood and, if possible, tissue samples will be obtained from all participants. Clinical details, laboratory results, imaging studies, and histopathological data at disease presentation will be retrieved. An initial screening will be performed by analyzing changes in the sequence of multiple genes that have been associated with the occurrence of …
This description comes directly from the study's public registry record.
Laura C Hernández Ramírez, MD, PhD · +525554870900 · laura.hernandez@cic.unam.mx
Claudia Ramírez Rentería, MD, MSc · +525556276900 · clau.r2000@gmail.com
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| Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social | Mexico City, Mexico City, Mexico | Recruiting |
| Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán | Mexico City, Mexico City, Mexico | Recruiting |
| Red de Apoyo a la Investigación, Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México | Mexico City, Mexico City, Mexico | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06523582