Condition: NASH · HCC · Genetic Predisposition · Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hepatocellular carcinoma (HCC) is the fifth most common solid cancer and the second cause of cancer-related mortality worldwide. Nonalcoholic fatty liver disease (NAFLD), that is hepatic accumulation of fat in excess of 5% not explained by at risk alcohol intake, is projected to become the leading cause of HCC in Western countries within 2025.NAFLD is most frequently caused by insulin resistance due to unhealthy lifestyle. Due to the epidemics of obesity and type 2 diabetes, NAFLD now affects one in three individuals worldwide. NAFLD-HCC frequently develops without overt cirrhosis suggesting that steatosis directly promotes hepatic carcinogenesis.
This description comes directly from the study's public registry record.
Luca Vittorio Carlo Valenti · 02 5503 6595 · luca.valenti@policlinico.mi.it
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| Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Istituto di Ricovero e Cura a Carattere Scientifico di natura pubblica | Milan, Milano, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06523179