Condition: Non Hodgkin Lymphoma · Sponsor: Michael Randall
This is a phase I/Ib imaging study of granzyme B, 64-copper granzyme targeting restricted interaction peptide specific to family member B (64Cu-GRIP B) Positron Emission Tomography (PET) in patients with relapsed/refractory non-Hodgkin's lymphoma (NHL) receiving CD19-directed Chimeric antigen receptor T cells (CAR-T) therapy. The proposed study represents the first-ever lymphoma patient imaging studies with 64Cu-GRIP B PET. The tracer is designed to detect extracellular granzyme B as it is secreted by activated immune cells in the tumor microenvironment, which may highlight tumors that will exhibit a durable response to Cluster of Differentiation 19 (CD19)-directed CAR T-cell therapy.
This description comes directly from the study's public registry record.
UCSF Hematopoietic Malignancies Clinical Trial Recruitment · 877-827-3222 · HDFCCC.Heme@ucsf.edu
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| University of California, San Francisco | San Francisco, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06522932