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Study identifier: NCT06522919 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sequential Immunochemotherapy Treatment with Pembrolizumab Plus Dendritic Cell (DC) Vaccine Followed by Trifluridine/Tipiracil Plus Bevacizumab in Refractory Mismatch-repair-proficient (pMMR) or Microsatellite-stable (MSS) Metastatic Colorectal Cancer

Condition: Colorectal Cancer Metastatic · Microsatellite Stable Colorectal Carcinoma · Refractory Mismatch-repair-proficient (pMMR) Metastatic Colorectal Cancer  ·  Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

PhasePhase 2
Planned participants36
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Single-arm, open-label, multicenter phase 2 clinical trial evaluating the clinical and the immunological activity of an innovative strategy with an induction combo immunotherapy (Pembrolizumab plus DC Vaccine) followed by a maintenance chemotherapy (FTD/TPI plus Bevacizumab) in patients with refractory MSS/pMMR metastatic colorectal cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Oriana Nanni  ·  0543739266  ·  oriana.nanni@irst.emr.it

Bernadette Vertogen  ·  0544286058  ·  bernadette.vertogen@irst.emr.it

Always discuss trial participation with your own doctor first.

Locations (2)

IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l.Meldola, Forlì Cesena, ItalyRecruiting
Pia Fondazione di Culto e Religione Azienda Ospedaliera "Card.G.Panico"Tricase, Lecce, ItalyNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06522919