Condition: Aging · Sponsor: VA Office of Research and Development
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.
This description comes directly from the study's public registry record.
Karin C Wu, MD · (415) 221-4810 · karin.Wu@va.gov
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| San Francisco VA Medical Center, San Francisco, CA | San Francisco, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06519877