Condition: HER2-positive Breast Cancer · Sponsor: Giampaolo Bianchini
This retrospective observational study aims at the comparison of the tumour-microenvironment tissue architecture before and after neo-adjuvant therapy in samples from HER2-positive (HER2+) breast cancer (BrCa) patients that display residual invasive disease in the breast/lymph node at surgery after standard-of-care combined chemotherapy and trastuzumab treatment. The working hypothesis of the investigators is that: Therapy imposes a selective pressure on tumour-microenvironment features promoting resistance to treatment. Participant that have already undergone neo-adjuvant treatment as part of their regular medical care for HER2-positive breast cancer will provide access to formalin-fixed paraffin-embedded (FFPE) samples taken before and after therapy. Tumoral, peri-tumoral and stromal regions of each specimen will be analyzed with the ultimate goal to identify new biomarkers (and putative targets) of resistance to therapy.
This description comes directly from the study's public registry record.
Tiziana Daniele, PhD · +39 02 2643 6381 · daniele.tiziana@hsr.it
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| IRCCS San Raffaele Hospital | Milan, Lombardy, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06518382