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Study identifier: NCT06517758 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

Condition: Generalized Myasthenia Gravis  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants146
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

The study is a randomized, double-blind, placebo-controlled, multicenter, Phase III study, to evaluate efficacy, safety and tolerability of iptacopan in patients with AChR+ gMG who are on stable SOC treatment. Participants who meet the eligibility criteria will be randomized in a ratio of 1:1, to receive either iptacopan or matching placebo, for 6 months (180 days) while continuing on a stable SOC treatment. The randomization will be stratified based on region.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111

Always discuss trial participation with your own doctor first.

Locations (125)

Honor Health Research InstituteScottsdale, Arizona, United StatesRecruiting
Fullerton Neuro and Headache CtrFullerton, California, United StatesRecruiting
SC3 Research PasadenaPasadena, California, United StatesRecruiting
California Pacific Medical CenterSacramento, California, United StatesRecruiting
Neurology Offices Of South FloridaBoca Raton, Florida, United StatesWithdrawn
Superior Associates in Research LLCHialeah, Florida, United StatesWithdrawn
Augusta University GeorgiaAugusta, Georgia, United StatesRecruiting
Hawaii Pacific Neuroscience LLCHonolulu, Hawaii, United StatesWithdrawn
University of Chicago Medical CentrChicago, Illinois, United StatesRecruiting
Prairie Heart InstituteSpringfield, Illinois, United StatesRecruiting
Mid Atlantic Epilepsy and Sleep CtrBethesda, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

+ 113 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06517758