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Study identifier: NCT06517511 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Selinexor in Combination With R-CHOP as the First-line Therapy for TP53-mutated DLBCL Patients (Smart Trial)

Condition: Diffuse Large B Cell Lymphoma  ·  Sponsor: Sun Yat-sen University

PhasePhase 2
Planned participants42
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This is a prospective, single-arm, multi-center, phase II clinical trial to evaluate the efficacy and safety of selinexor in combination with R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone) followed by selinexor maintenance for untreated TP53-mutated diffuse large B-cell lymphoma (DLBCL) patients.

This description comes directly from the study's public registry record.

Talk to the study team

QingQing Cai, MD. PhD.  ·  0086-20-87342823  ·  caiqq@sysucc.org.cn

Yi Xia, MD. PhD.  ·  0086-20-87342823  ·  xiayi@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (2)

Sun yat-sen university cancer centerGuangzhou, Guangdong, ChinaRecruiting
Fudan University Shanghai Cancer CenterShanghai, Shanghai Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06517511