Condition: Long-standing Persistent Atrial Fibrillation · Ablation · Sponsor: The First Affiliated Hospital with Nanjing Medical University
Catheter ablation has become as the first-line treatment for patients with symptomatic atrial fibrillation (AF). As the cornerstone of catheter ablation for AF, the safety and efficacy of circumferential pulmonary vein isolation (CPVI) have been confirmed. However, for persistent AF, especially for long-standing persistent AF (LSPAF), the recurrence rate is still high. Whether the ethanol infusion (EI) into the vein of Marshall (EI-VOM) and linear ablation could improve the success rate remains controversial. The SINUS study is a prospective, multicenter, randomized trial, which is designed to compare the efficacy and safety between CPVI with modified linear ablation (CPVI-MLA) and CPVI only for the treatment of LSPAF.
This description comes directly from the study's public registry record.
Yan Dong, MD · +86 18651908170 · dy_medical@163.com
Qiushi Chen, MD · chenqs918@163.com
Always discuss trial participation with your own doctor first.
| Beijing Anzhen Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Peking University third hospital | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Sun Yat-sen Memorial Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Shenzhen Hospital, Fuwai Hospital, Chinese Academy of Medical Science | Shenzhen, Guangdong, China | Not Yet Recruiting |
| Zhengzhou University People's Hospital, Henan Provincial People's Hospital | Zhengzhou, Henan, China | Recruiting |
| The First Affiliated Hospital of Nanjing Medical University | Nanjing, Jiangsu, China | Recruiting |
| The First Affiliated Hospital of Dalian Medical University | Dalian, Liaoning, China | Not Yet Recruiting |
| The First Affiliated Hospital of Shandong First Medical University | Jinan, Shandong, China | Not Yet Recruiting |
| Xijing Hospital, Air Force Medical University | Xi’an, Shanxi, China | Not Yet Recruiting |
| Taizhou First People's Hospital | Taizhou, Zhejiang, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06516822