Condition: Lactose Intolerance · Lactose Intolerant · Lactase Persistence · Sponsor: Albert Einstein College of Medicine
Individuals with lactase non-persistence (LNP; determined by a functional variant in the LCT gene \[rs4988235, GG genotype\]) are susceptible to lactose intolerance in adulthood due to deficiency of lactase, the enzyme which digests milk lactose sugars. However, many LNP individuals still drink ≥1 cup of milk daily. Recent analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) found that consumption of 1 serving (cup) of milk/day was associated with \~30% lower risk of type 2 diabetes among LNP individuals, but not among individuals with lactase persistence (LP). This beneficial effect might be partially explained by favorable alterations in gut microbiota and related metabolites associated with higher milk consumption among LNP individuals. Based on these observational study findings, the investigator team proposes to conduct a randomized, controlled trial of lactose-containing vs. lactose-free milk in LNP individuals with pre-diabetes, to comprehensively investigate the effects of milk intake on the gut microbiome and glycemic outcomes.
This description comes directly from the study's public registry record.
Brandilyn Peters-Samuelson, PhD · 718-430-3281 · brandilyn.peterssamuelson@einsteinmed.edu
Qibin Qi, PhD · 718-430-4203 · qibin.qi@einsteinmed.edu
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| HCHS/SOL Bronx Field Center | The Bronx, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06513026