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Study identifier: NCT06507618 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Pre-Operative Window of ET to Inform RT Decisions (POWER II)

Condition: Breast Cancer Female  ·  Sponsor: University of Virginia

PhasePhase 3
Planned participants354
Who can joinFemale, 65 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase III, multisite exploratory study for women ≥ 65 years of age with early stage estrogen receptor positive (ER+) breast cancer. These individuals will be treated randomly assigned to one of two groups: Intervention, treated with 3 months of pre-operative endocrine therapy (pre-ET) OR Control, participants follow standard of care and proceed directly to breast cancer surgery. Both arms will be assessed for tolerance and compliance to the endocrine therapy by patient reported outcome (PRO) measures (patient surveys).

This description comes directly from the study's public registry record.

Talk to the study team

Meagan Miller  ·  434-243-8101  ·  aey8fc@uvahealth.org

Always discuss trial participation with your own doctor first.

Locations (6)

Yale UniversityNew Haven, Connecticut, United StatesRecruiting
University of VirginiaCharlottesville, Virginia, United StatesRecruiting
University of Virginia Community HealthCulpeper, Virginia, United StatesRecruiting
INOVA Schar CancerFairfax, Virginia, United StatesRecruiting
Riverside Health SystemNewport News, Virginia, United StatesRecruiting
Virginia Commonwealth UniversityRichmond, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06507618