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Study identifier: NCT06504940 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Optimize Study - Orelabrutinib Combined With BR/G in Untreated Marginal Zone Lymphoma (MZL)

Condition: Marginal Zone Lymphoma  ·  Sponsor: First Affiliated Hospital of Zhejiang University

PhasePhase 2
Planned participants69
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multi-center, prospective cohort study. The main purpose of Cohort A is to evaluate the efficacy and safety of Orelabrutinib combined with BR (bendamustine and rituximab) for previously untreated young patients with MZL; the purpose of Cohort B is to assess the efficacy and safety of Orelabrutinib combined with G (Obinutuzumab) followed by Orelabrutinib maintenance therapy for previously untreated elderly patients with MZL.

This description comes directly from the study's public registry record.

Talk to the study team

Xuewu Zhang  ·  +86 15168316013  ·  moyu0718@126.com

Wenjuan Yu  ·  yyu@zju.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

The First Affiliated Hospital ,Zhejiang University School of MedicineHangzhou, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06504940