Condition: Endometriosis · Infertility · Sponsor: University Hospital, Toulouse
Endometriosis is an estrogen-dependent, chronic inflammatory gynecologic disease affecting women of reproductive age, with a therapeutic wandering of 6 to 10 years. A better understanding of the initiation phase is a major challenge to improve diagnosis and treatment. The most widely accepted hypothesis to explain the formation of endometriotic lesions is the tubal retrograde reflux during menstruation. However, only 10% of the reproductive age women will develop endometriosis while 90% of women experience retrograde menstruation. This raises the question of the stem cells present in the endometrium and menstrual reflux of these patients, but also of both the peritoneal microenvironment and the estrogenic local signaling which allow the implantation of these lesions.
This description comes directly from the study's public registry record.
Elodie CHANTALAT, MD · 0561323953 · chantalat.e@chu-toulouse.fr
Françoise LENFANT, PhD · francoise.lenfant@inserm.fr
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| University Hospital Toulouse | Toulouse, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06502548