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Study identifier: NCT06500676 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

Condition: KRAS G12D Mutations · Advanced Solid Tumors  ·  Sponsor: Genfleet Therapeutics (Shanghai) Inc.

PhasePhase 1/Phase 2
Planned participants407
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a multicenter, open-label, phase I/II study to explore the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of GFH375 in patients with advanced solid tumors harboring a KRAS G12D mutation.

This description comes directly from the study's public registry record.

Talk to the study team

Yolanda Zeng  ·  +86 21 6882 1388  ·  yaozeng@genfleet.com

Always discuss trial participation with your own doctor first.

Locations (20)

The First Affiliated Hospital of Anhui Medical UniversityHefei, Anhui, ChinaNot Yet Recruiting
Cancer Hospital, Chinese Academy of Medical SciencesBeijing, Beijing Municipality, ChinaRecruiting
Peking Union Medical College HospitalBeijing, Beijing Municipality, ChinaRecruiting
Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, ChinaRecruiting
The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, Guangdong, ChinaRecruiting
Guangxi Medical University Cancer HospitalNanning, Guangxi, ChinaNot Yet Recruiting
Harbin Medical University Cancer HospitalHaerbin, Heilongjiang, ChinaNot Yet Recruiting
The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, Henan, ChinaRecruiting
Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan, Hubei, ChinaRecruiting
Hunan Cancer HospitalChangsha, Hunan, ChinaRecruiting
Jiangsu Province HospitalNanjing, Jiangsu, ChinaRecruiting
Liaoning Cancer Hospital & InstituteShenyang, Liaoning, ChinaNot Yet Recruiting

+ 8 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06500676