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Study identifier: NCT06494904 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Standard Versus High Dose ED-Initiated Buprenorphine Induction

Condition: Opioid Use Disorder  ·  Sponsor: Yale University

PhasePhase 3
Planned participants360
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This study is a multisite double-blind, double-dummy, randomized clinical trial enrolling ED patients with untreated moderate to severe opioid use disorder (OUD) to compare Standard Dose Induction (SDI) and High Dose Induction (HDI) on rates of participation in OUD treatment within 10 days post randomization, and opioid withdrawal symptoms, opioid craving, and use of illicit and non-prescribed drugs.

This description comes directly from the study's public registry record.

Talk to the study team

Gail D'Onofrio, MD, MS  ·  2037857059  ·  gail.donofrio@yale.edu

Kathryn Hawk, MD, MHS  ·  2037857899  ·  kathryn.hawk@yale.edu

Always discuss trial participation with your own doctor first.

Locations (5)

Highland HospitalOakland, California, United StatesRecruiting
San Leandro HospitalSan Leandro, California, United StatesRecruiting
Maine Medical CenterPortland, Maine, United StatesRecruiting
Cooper University HospitalCamden, New Jersey, United StatesRecruiting
University of Utah HospitalSalt Lake City, Utah, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06494904