Condition: Non-squamous Metastatic Non-Small-Cell Lung Carcinoma · Sponsor: AstraZeneca
This prospective, multicenter, non-interventional study (NIS) in Germany aims to collect real-life data of patients with non-squamous (NSQ) metastatic non-small cell lung cancer (mNSCLC) (incl. large cell neuroendocrine carcinoma (LCNEC) if considered NSCLC-like by the treating physician) for whom 1st line treatment initiation with tremelimumab and durvalumab in combination with a platinum-based chemotherapy (TDC) according to marketing authorization was scheduled. The study aims to describe the effectiveness with respect to mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS), Serine/threonine kinase 11 (STK11), Kelch-like ECH-associated protein 1 (KEAP1), and Tumor protein p53 (TP53) as well as expression of Thyroid transcription factor 1 (TTF-1) and Programmed death-ligand 1 (PD-L1) in routine clinical practice. The generated data aims to deepen the understanding of optimal, biomarker-guided treatment strategies for NSQ mNSCLC in distinct subgroups with a high medical need.
This description comes directly from the study's public registry record.
AstraZeneca Clinical Study Information Center · 1-877-240-9479 · information.center@astrazeneca.com
Always discuss trial participation with your own doctor first.
| Research Site | Bad Homburg, Germany | Recruiting |
| Research Site | Berlin, Germany | Recruiting |
| Research Site | Bremen, Germany | Recruiting |
| Research Site | Celle, Germany | Withdrawn |
| Research Site | Chemnitz, Germany | Recruiting |
| Research Site | Cologne, Germany | Recruiting |
| Research Site | Deggendorf, Germany | Recruiting |
| Research Site | Frankfurt, Germany | Recruiting |
| Research Site | Georgsmarienhütte, Germany | Recruiting |
| Research Site | Gera, Germany | Withdrawn |
| Research Site | Goslar, Germany | Recruiting |
| Research Site | Greifswald, Germany | Recruiting |
+ 17 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06494540