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Study identifier: NCT06494085 Synced from ClinicalTrials.gov · July 29, 2026
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Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation

Condition: Acute Hypoxemic Respiratory Failure  ·  Sponsor: Unity Health Toronto

PhaseN/A
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator. This support aims at avoiding excessive inspiratory effort, while ensuring a certain degree of training of the patient's inspiratory muscle. Avoiding both minimal and excessive assistance is thus important for the optimal care of the intubated patient ensuring a lung and diaphragm protective ventilation with the goal to liberate the patient from the ventilator as soon as possible. Recently pressure-muscle-index (PMI), an index of inspiratory effort easy to be measured on the ventilator screen, has been proposed to avoid excessive assistance in PSV. This will be the first prospective study testing the effects of setting pressure support based on PMI to avoid excessive assistance on patients recovering from acute lung injury (acute hypoxemic respiratory failure).

This description comes directly from the study's public registry record.

Talk to the study team

Laurent Brochard, MD, PhD  ·  4168645686  ·  laurent.brochard@unityhealth.to

Always discuss trial participation with your own doctor first.

Locations (1)

St. Michael's HospitalToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06494085