Condition: Breast Cancer · Sponsor: Helwan University
The goal of this clinical trial is to learn if dapagliflozin drug has a cardioprotective effect against anthracyclines-induced cardiotoxicity. It will also learn about the safety of dapagliflozin drug. Aim of the study: Evaluate cardioprotective effect and safety of dapagliflozin against anthracyclines-induced cardiotoxicity. The main questions it aims to answer are: 1. Does the drug lower the cardiotoxicity which induced by anthracyclines? 2. What medical problems do participants have when taking dapagliflozin drug? Treatment 1. Anthracyclines by 4 cycles included doxorubicin 50-60 mg/m2 with cyclophosphamide 600 mg as a combination or epirubicin 90-100 mg/m2 with cyclophosphamide 600 mg as a combination. 2. Dapagliflozin 10 mg tablet orally, once daily. Started 7 days before the first cycle of anthracyclines till the end of last anthracyclines dose.
This description comes directly from the study's public registry record.
Shimaa Nabil Abd elaziz Hassanein, bachelor · +201115817090 · Shimaa.Nabil@pharm.helwan.edu.eg
Sara Mohamed Mohamed, Lecturer · +201016903404 · Sara.abdel-motaleb@pharm.helwan.edu.eg
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| Al demerdash hospital at oncology departement | Cairo, Cairo Governorate, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06491680