Condition: Inflammatory Hepatocellular Adenoma · Sponsor: Assistance Publique - Hôpitaux de Paris
Hepatocellular adenomas (HCA) are tumors rare benign hepatic infections that develop on a liver normal and in young women taking a estrogen-based contraception. The main molecular subgroup of AHCs is the AHC subgroup inflammatory, which are associated with a risk of bleeding from the tumor and malignant transformation. Therefore, most of women with large inflammatory AHC (\>5 cm) require liver resection which can be associated with morbidity and aesthetic problems, and rarely to mortality. On the basis of the knowledge of the molecular classification of AHCs humans and preclinical data testing the JAK1/2 inhibitors, we hypothesize that a short duration of treatment with the inhibitor of JAK1/2 (baricitinib) may be effective in patients with large inflammatory AHC size.
This description comes directly from the study's public registry record.
Jean Charles NAULT, PUPH · 00336 10 67 94 61 · jean-charles.nault@aphp.fr
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| NAULT | Bobigny, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06490757