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Study identifier: NCT06488625 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety of Oral Controlled-Ileocolonic-Release Nicotinamide (CICR-NAM) in Patients With Mild to Moderately Active Ulcerative Colitis

Condition: Ulcerative Colitis, Unspecified  ·  Sponsor: University Hospital Schleswig-Holstein

PhasePhase 2/Phase 3
Planned participants459
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

Double-blind, randomised, placebo-controlled phase II / III trial evaluating efficacy and safety of two different doses (2 g/d or 3 g/d) of oral controlled-ileocolonic-release nicotinamide (CICR-NAM) compared to placebo in patients with ulcerative colitis (UC). The intended therapeutic use of CICR-NAM is to improve intestinal inflammation in adults with UC by topically increasing nicotinamide supply in the ileocolonic region and thus favourably influencing the composition of intestinal microbiota

This description comes directly from the study's public registry record.

Talk to the study team

Stefan Schreiber, Prof. Dr. Dr. hc.  ·  +4943150022200  ·  s.schreiber@mucosa.de

Friso Muijsers  ·  +4943150030751  ·  info@zks.uni-kiel.de

Always discuss trial participation with your own doctor first.

Locations (26)

Universitaetsklinikum Schleswig-Holstein AöRKiel, Schleswig-Holstein, GermanyRecruiting
Universitaetsklinikum Aachen AöRAachen, GermanyNot Yet Recruiting
Universitaetsklinikum AugsburgAugsburg, GermanyRecruiting
Sozialstiftung BambergBamberg, GermanyRecruiting
Charite Universitaetsmedizin Berlin KöRBerlin, GermanyRecruiting
Charite Universitaetsmedizin Berlin KöRBerlin, GermanyRecruiting
DRK Kliniken BerlinBerlin, GermanyRecruiting
Gesundheit Nord gGmbH Klinikverbund BremenBremen, GermanyRecruiting
Evangelisches Krankenhaus Kalk gGmbHCologne, GermanyRecruiting
Medical Care Unit DachauDachau, GermanyWithdrawn
Gastroenterologie am HerrengartenDarmstadt, GermanyRecruiting
Gastroenterologische Schwerpunktpraxis Prof. Dr. Ludwig & Dr. med. GüthleDornstadt, GermanyRecruiting

+ 14 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06488625