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Study identifier: NCT06488378 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

Condition: Breast Cancer · PALB2-Mutated Breast Carcinoma · HER2-negative Breast Cancer  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 1
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research is being done to evaluate the safety and tolerability of the new drug, axatilimab, in combination with olaparib (a standard of care treatment) in Breast Cancer 1/2 genes (BRCA 1/2) and PALB2 associated HER2-negative metastatic breast cancer. The names of the study drugs involved in this study are: * Axatilimab (a type of antibody) * Olaparib (a type of PARP inhibitor)

This description comes directly from the study's public registry record.

Talk to the study team

Filipa Lynce, MD  ·  617-632-2335  ·  filipa_lynce@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06488378