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Study identifier: NCT06484491 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

IMPT Dose Escalation for NSCLC (HyDose)

Condition: Carcinoma, Non-Small-Cell Lung  ·  Sponsor: University Medical Center Groningen

PhaseNA
Planned participants87
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical pilot trial is to learn if dose to the tumor in the lung can be safely increased using proton therapy in stage III non-small-cell lung cancer patients receiving combined chemotherapy and radiotherapy. The main questions it aims to answer are: * Is the risk of severe radiotherapy toxicities (requiring hospital admission) within acceptable margins ? * What is a rough estimate of the effect of the treatment under study? Compared to standard care in our clinic, all participants in this pilot trial will * Receive a higher dose of proton therapy to the tumor in the lung albeit with the same number of radiotherapy visits as the current standard treatment. * Receive two additional follow-up visits at the clinic after treatment, namely 4 and 6 weeks after finishing radiotherapy. * Two additional blood withdrawals at the last week of radiotherapy and 4 weeks after finishing radiotherapy, to measure a type of white blood cells. * Receive an extra quality of life questionnaire at the last week of radiotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

A. Hessels, MD PhD  ·  06-25648774  ·  a.c.hessels@umcg.nl

Always discuss trial participation with your own doctor first.

Locations (1)

UMCGGroningen, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06484491