Condition: Traumatic Brain Injury With Loss of Consciousness · Brain Injury Traumatic Severe · Brain Injury Traumatic Moderate · Sponsor: University of Texas Southwestern Medical Center
Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\< 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.
This description comes directly from the study's public registry record.
Kan Ding, MD · 214-648-3571 · kan.ding@utsouthwestern.edu
Jill Morales, MS · 214-648-3571 · Epitbiresearch@utsouthwestern.edu
Always discuss trial participation with your own doctor first.
| Texas Health Presbyterian Hospital | Dallas, Texas, United States | Recruiting |
| Parkland Health and Hospital System | Dallas, Texas, United States | Recruiting |
| UT Southwestern Medical Center | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06480838