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Study identifier: NCT06480539 Synced from ClinicalTrials.gov · July 28, 2026
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The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study

Condition: Postoperative Fatigue · Postoperative Sleep Disturbances · Surgical Stress Response  ·  Sponsor: Ziekenhuis Oost-Limburg

PhasePhase 4
Planned participants102
Who can joinAll sexes, 60 Years to no upper limit
Healthy volunteersNo

About this study

In the aftermath of major surgery, many patients suffer from pain, fatigue, reduced general well-being, and cognitive dysfunction. Another common concern after major surgery is sleep impairment and there is little known about its effect on postoperative morbidity, especially postoperative fatigue and muscle function. Dexmedetomidine has been shown to possibly improve postoperative sleep quality in critically ill patients. However, whether the administration of dexmedetomidine translates into reduced postoperative fatigue and/or weakness and improved enhanced recovery after surgery by improving sleep, is currently unknown. The DEXSLEEP study will evaluate the effect of nocturnal administration of dexmedetomidine, as compared to placebo (i.e. no dexmedetomidine), on postoperative quality of recovery, postoperative fatigue and muscle weakness.

This description comes directly from the study's public registry record.

Talk to the study team

Steven Thiessen  ·  3289325294  ·  steven.thiessen@zol.be

Always discuss trial participation with your own doctor first.

Locations (1)

Ziekenhuis Oost-LimburgGenk, Limburg, BelgiumRecruiting

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Source record: clinicaltrials.gov/study/NCT06480539