Condition: Immune Thrombocytopenia With Positive ANA Antibodies · Sponsor: Yunfeng Cheng
The goal of this clinical trial is to learn if hydroxychloroquine (HCQ) plus thrombopoietin receptor agonists (TPO-RA) works to treat primary immune thrombocytopenia with positive anti-nuclear antibodies in adults. It will also learn about the safety of HCQ plus TPO-RA. The main questions it aims to answer are: Does HCQ plus TPO-RA raise the response rate in participants, compared to TPO-RA alone? Does HCQ plus TPO-RA prolong the response duration in participants, compared to Pred alone? Does HCQ plus TPO-RA decrease the dose of TPO-RA to maintain response in participants, compared to TPO-RA alone? What medical problems do participants have when taking HCQ plus TPO-RA? Researchers will compare HCQ plus TPO-RA with TPO-RA alone to see if HCQ plus TPO-RA works better to treat primary immune thrombocytopenia with positive anti-nuclear antibodies. Participants will: Take TPO-RA every day for no more than 24 weeks, adjust the dose of TPO-RA according to the platelet level, with or without HCQ twice a day for 1 year; Visit the clinic once every 1 weeks for the first 8 weeks, and once every 2-4 weeks in the following 10 months for checkups and tests; Keep a diary of their symptoms
This description comes directly from the study's public registry record.
Lili Ji · 86-021-64041990 · ji.lili@zs-hospital.sh.cn
Always discuss trial participation with your own doctor first.
| Shanghai Zhongshan Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Wusong Hospital, Zhongshan Hospital, Fudan University | Shanghai, Shanghai Municipality, China | Recruiting |
| Shanghai Jinshan Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Qingpu Branch of Zhongshan Hospital, Fudan University | Shanghai, Shanghai Municipality, China | Recruiting |
| Health and Humanity Research Centre, Hongkong, China. | Hong Kong, Hong Kong | Recruiting |
| Dr. Stanley Ho Medical Foundation | Macao, Macau | Recruiting |
| University Hospital, Macau University of Science and Technology. | Macao, Macau | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06479291