Condition: Myelofibrosis · Post-PV MF · Post-ET Myelofibrosis · Sponsor: Kartos Therapeutics, Inc.
This clinical trial is evaluating whether addition of navtemadlin to ruxolitinib treatment will provide more clinical benefit than ruxolitinib alone for patients with Myelofibrosis who have a suboptimal response to ruxolitinib treatment alone. Subjects will start by receiving ruxolitinib alone in the run-in period. Those who demostrate a suboptimal response from ruxolitinib alone will then be randomized 2:1 to receive navtemadlin or navtemadlin placebo as add-on treatment to their ongoing ruxolitinib. Randomized means that subjects will be assigned to a group by chance, like a flip of a coin. The study is blinded, meaning the subjects, doctors, central endpoint assessors and sponsor will not know which add on treatment (navtemadlin or navtemadlin placebo) the subject is receiving.
This description comes directly from the study's public registry record.
John Mei · 650-542-0136 · jmei@kartosthera.com
Always discuss trial participation with your own doctor first.
| UAB Hospital | Birmingham, Alabama, United States | Recruiting |
| Banner MD Anderson Cancer Center | Gilbert, Arizona, United States | Recruiting |
| Mayo Clinic - Phoenix | Phoenix, Arizona, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| UCLA Hematology/Oncology Clinic - Los Angeles | Los Angeles, California, United States | Recruiting |
| Scripps Health, Prebys Cancer Center | San Diego, California, United States | Recruiting |
| The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance, California, United States | Recruiting |
| Rocky Mountain Cancer Centers - Aurora | Aurora, Colorado, United States | Recruiting |
| Medical Oncology Hematology Consultants, PA | Newark, Delaware, United States | Recruiting |
| MedStar Georgetown University Hospital, Lombardi Comprehensive Cancer Center | Washington D.C., District of Columbia, United States | Recruiting |
| Mayo Clinic - Jacksonville | Jacksonville, Florida, United States | Recruiting |
| University of Miami | Miami, Florida, United States | Recruiting |
+ 203 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06479135