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Study identifier: NCT06477991 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial.

Condition: Clinical Complete Response Rate With Negative MRD  ·  Sponsor: Yunnan Cancer Hospital

PhaseN/A
Planned participants22
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study is a single arm, single center, phase II, prospective clinical study aimed at exploring the effectiveness and safety of watch and wait strategy guided by dynamic minimal disease residual (MRD) monitoring to achieve clinical complete response after neoadjuvant immunotherapy for locally advanced colorectal cancer with deficient mismatch repair/ microsatellite instability-high (dMMR/MSI-H).

This description comes directly from the study's public registry record.

Talk to the study team

Xuan Zhang, doctor  ·  +86 173 8791 1546  ·  zhangxuan66@kmmu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Yunnan Cancer HospitalKunming, Yunnan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06477991