Condition: Tuberculosis, Pulmonary · Sponsor: Makerere University
The goal of this clinical trial is to assess the efficacy(effectiveness) of doxycycline, a potent inhibitor of matrix metalloproteinase (lung collagenase) activity in prevention of Tuberculosis associated lung fibrosis and associated lung function decline among patients with drug sensitive advanced TB. The main question\[s\] it aims to answer are: * Does doxycycline have a significant anti-fibrosis role when given as adjuvant therapy to TB patients with advanced pulmonary TB in a double blind randomized placebo controlled trial? * How does long term respiratory function defer between patients who received adjuvant doxycycline aimed at prevention of TB associated lung fibrosis and those who received a placebo in a double blind randomized controlled trial? Participants will be subjected to the following: * Experimental arm: Doxycycline 100 mg once daily for 12 weeks administered concurrently with standard of care anti-TBs. * Comparator arm: Placebo once daily for 12 weeks administered concurrently with standard of care anti-TBs.
This description comes directly from the study's public registry record.
Ahmed Ddungu, MBCHB,MMED · 0782303377 · ahddungu@yahoo.com
Always discuss trial participation with your own doctor first.
| Makerere University Lung Institute | Kampala, Kampala, Uganda | Not Yet Recruiting |
| Mulago National Referral Hospital | Kampala, Uganda | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06477185