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Study identifier: NCT06476119 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

OPTImaL:Optimisation of Treatment for Patients With Low Stage Triple-negative Breast Cancer With High Stromal Tumor-infiltrating Lymphocytes

Condition: Breast Cancer Stage I · Triple Negative Breast Cancer (TNBC)  ·  Sponsor: The Netherlands Cancer Institute

PhaseN/A
Planned participants490
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The aim of this study is to investigate whether subjects with breast cancer that have certain favorable features, after performing the surgery and radiation, the chemotherapy can be safely omitted in the treatment. In addition, the investigation looks at whether the omission of chemotherapy ensures a better quality of life. Participants decide, in consultation with their treating physician, whether they choose to be treated with adjuvant chemotherapy or not.

This description comes directly from the study's public registry record.

Talk to the study team

Marleen Kok, MD  ·  +31205129111  ·  m.kok@nki.nl

Rianne Rolfes, MD  ·  +31205129111  ·  r.rolfes@nki.nl

Always discuss trial participation with your own doctor first.

Locations (28)

Zuyderland Medisch CentrumSittard-Geleen, Limburg, NetherlandsNot Yet Recruiting
Medical spectrum TwenteEnschede, Overijssel, NetherlandsRecruiting
Noordwest ZiekenhuisgroepAlkmaar, NetherlandsNot Yet Recruiting
FlevoziekenhuisAlmere Stad, NetherlandsNot Yet Recruiting
Meander Medisch CentrumAmersfoort, NetherlandsRecruiting
Antoni van LeeuwenhoekAmsterdam, NetherlandsRecruiting
Onze Lieve Vrouwe Gasthuis (OLVG)Amsterdam, NetherlandsRecruiting
RijnstateArnhem, NetherlandsRecruiting
Amphia ziekenhuisBreda, NetherlandsRecruiting
Deventer ZiekenhuisDeventer, NetherlandsRecruiting
Ziekenhuis Gelderse ValleiEde, NetherlandsRecruiting
Catharina ZiekenhuisEindhoven, NetherlandsRecruiting

+ 16 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06476119