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Study identifier: NCT06475352 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Dose Individualization of Chemotherapy in Patients With Gastrointestinal Cancers Lacking a Specific Liver Enzyme

Condition: Digestive Cancer · Colorectal Cancer  ·  Sponsor: UNICANCER

PhasePhase 2
Planned participants400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to establish guidelines for fluoropyrimidine dose reduction according to uracilemia in patients with DPD deficiency in the treatment of digestive cancers. The main question it aims to answer is: \- Which reduction dose of fluoropyrimidine is needed for patient with DPD deficiency? Participants will: * Take the treatment with the reduction of dose stated by the protocol * Visit the clinic once every 2-3 weeks for checkups and tests for collection of adverse events

This description comes directly from the study's public registry record.

Talk to the study team

Nicolas DE SOUSA CARVALHO  ·  01 71 93 67 09  ·  n-de-sousa@unicancer.fr

Laure MONARD  ·  01 73 79 73 09  ·  l-monard@unicancer.fr

Always discuss trial participation with your own doctor first.

Locations (41)

CHU AmiensAmiens, FranceRecruiting
Hopital Henri MondorAurillac, FranceRecruiting
Institut du Cancer Avignon ProvenceAvignon, FranceRecruiting
CH Aunay BayeuxBayeux, FranceRecruiting
CH Cote BasqueBayonne, FranceRecruiting
CHU BesançonBesançon, FranceRecruiting
Centre François BaclesseCaen, FranceRecruiting
Polyclinique du Parc - Centre d'Oncologie Maurice TubianaCaen, FranceRecruiting
Infirmerie ProtestanteCaluire-et-Cuire, FranceNot Yet Recruiting
CHU Clermont FerrandClermont-Ferrand, FranceNot Yet Recruiting
Hopital BeaujonClichy, FranceRecruiting
Hopital Henri MondorCréteil, FranceRecruiting

+ 29 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06475352