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Study identifier: NCT06475235 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

Condition: Lymphoma · Primary Central Nervous System Lymphoma  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 1
Planned participants15
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is studying if the investigational drug, Pembrolizumab, in combination with chemotherapy helps primary central nervous system lymphoma with acceptable side effects. This research study involves a combination of the below drugs: * Pembrolizumab (a type of monoclonal antibody) * Methotrexate (a type of anti-metabolite) * Temozolomide (a type of alkylating agent) * Rituximab (a type of antibody)

This description comes directly from the study's public registry record.

Talk to the study team

Lakshmi Nayak, MD  ·  617-632-2166  ·  Lakshmi_Nayak@DFCI.HARVARD.EDU

DFCI Clinical Trials Hotline  ·  877-338-7425

Always discuss trial participation with your own doctor first.

Locations (2)

Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06475235