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Study identifier: NCT06474507 Synced from ClinicalTrials.gov · July 29, 2026
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Efficacy and Safety of Calculus Bovis Sativus (CBS) for Ischemic Cerebral Vascular Disease (CBSinICVD)

Condition: Ischemic Cerebrovascular Disease · Acute Ischemic Stroke · Cerebral Small Vessel Diseases  ·  Sponsor: Tongji Hospital

PhaseNA
Planned participants230
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

The most common cause of death for Chinese patients is ischemic cerebrovascular diseases(ICVD), particularly cerebral infarction. It places a heavy burden on people, families, and society as a whole and poses considerable risks of death and disability. The disease known as CSVD has a subtle beginning, is difficult to identify, and is frequently detected only after it progresses to the point of vascular cognitive dysfunction. The primary ischemia necrosis of brain nerve cells and the activation of inflammatory cells are their pathologic processes. According to historical Chinese medical documents, bezoar possesses properties that can help prevent seizures, treat strokes, enhance cognitive function and mental well-being, and stimulate alertness. Calculus Bovis Sativus (CBS) is the most authentic formulation of bezoar ingredients compared to other bezoar products. It has received approval from the China Food and Drug Administration for the essential treatment of comatose patients. CBS consists of three primary constituents: bilirubin, bile acids, and taurine. Scientific evidence has demonstrated that all of these components possess anti-inflammatory, antioxidant, and neuroprotective properties. The investigators' objective is to carry out an investigator-initiated clinical study to assess the efficacy of orally administered CBS in treating ischemic cerebrovascular diseases in humans.

This description comes directly from the study's public registry record.

Talk to the study team

Ke Shang, MD  ·  86-27-83663337  ·  kay_sang@qq.com

Ke Shang, MD  ·  86-27-83663332  ·  kay_sang@hust.edu.cn

Always discuss trial participation with your own doctor first.

Locations (2)

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhan, Hubei, ChinaRecruiting
Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hubei, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06474507