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Study identifier: NCT06473740 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Endovascular Plus GENe Therapy Versus Only EndoVascular Therapy for Severe Limb ischaemiA Trial

Condition: Severe Lower Limb Ischemia  ·  Sponsor: Amur State Medical Academy

PhasePhase 4
Planned participants386
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

GENEVA is the world's first multicenter, randomized, prospective, controlled trial of the clinical effectiveness of best endovascular treatment versus best endovascular treatment combined with gene therapy for severe lower limb ischemia (Rutherford categories 4 and 5). The researchers hypothesized that the combination treatment would significantly reduce the number of re-interventions on the operated segment and high amputations, and also significantly increase the time interval between re-interventions.

This description comes directly from the study's public registry record.

Talk to the study team

Alrxander Korotkikh, PhD  ·  +7 (922) 079-06-22  ·  dr.alex.korotkikh@gmail.cpm

Sergey Radaev  ·  +70(969) 255-14-30  ·  radaev@nextgene.ru

Always discuss trial participation with your own doctor first.

Locations (1)

Amur State Medical AcademyBlagoveshchensk, Amur Oblast, RussiaRecruiting

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Source record: clinicaltrials.gov/study/NCT06473740