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Study identifier: NCT06472583 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Preoperative Immunotherapy Combined With Stereotactic Radiation Therapy Boost in the Treatment of HER2-negative Breast Cancer

Condition: Breast Cancer  ·  Sponsor: Maria Sklodowska-Curie National Research Institute of Oncology

PhasePhase 2
Planned participants78
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

The goal of the study is to assess the safety and effectiveness of the combination of anti-PD1 immunotherapy (pembrolizumab) and radiotherapy in the preoperative treatment of HER2-negative breast cancer resistant to classical chemotherapy. The subject of the intervention will be: 1. Randomly assigned in a 2:1 ratio and double-blinded addition of pre-operative immunotherapy with pembrolizumab or placebo to standard chemotherapy 2. Addition of preoperative radiotherapy boost delivered with a CyberKnife radiosurgery system concomitantly with the use of paclitaxel (+/- carboplatin) and pembrolizumab / placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Michal Jarzab  ·  48322788716  ·  michal.jarzab@gliwice.nio.gov.pl

Always discuss trial participation with your own doctor first.

Locations (1)

Maria Sklodowska-Curie National Research Institute of Oncology , Gliwice BranchGliwice, PolandRecruiting

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Source record: clinicaltrials.gov/study/NCT06472583