Condition: Neuroendocrine Tumors · Progression · Neuroendocrine Tumor Grade 1 · Sponsor: AC Camargo Cancer Center
Everolimus is approved in many countries to treat patients with advanced/metastatic well-differentiated neuroendocrine tumors (NET), providing median progression-free survival times of approximately 12 months across different types of NET. However, it is can cause severe adverse effects. Phase I trial demonstrated that a dose of 5mg/day/week was sufficient to inhibit cell proliferation by blocking the mTOR pathway. This is a randomized, open-label, phase II near-equivalence clinical trial of oral everolimus 5 mg vs 10 mg oral/daily and continuously in patients with Grade 1 or Grade 2 metastatic NET, with tumor progression or intolerance to at least one line of treatment and with radiological disease progression within 6 months.
This description comes directly from the study's public registry record.
Rachel P Riechelmann, MD · +55112189500 · rachel.riechelmann@accamargo.org.br
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| AC Camargo Cancer Center | São Paulo, São Paulo, Brazil | Recruiting |
| AC Camargo Cancer Center | São Paulo, Brazil | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06472388