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Study identifier: NCT06472245 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

Condition: Patients With Non-Small Cell Lung Cancer  ·  Sponsor: OSE Immunotherapeutics

PhasePhase 3
Planned participants363
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Multicenter, randomized (2:1), open-label phase 3 study in HLA-A2 positive patients with squamous and non-squamous metastatic NSCLC with ICI secondary resistance. Patients will be randomized into 2 arms (randomization 2:1): experimental Arm A with OSE2101 monotherapy or control Arm B SoC with docetaxel monotherapy. Stratification factors will be histology (squamous versus non squamous) and ECOG Performance Status (0 versus 1).

This description comes directly from the study's public registry record.

Talk to the study team

Caroline Chevalier, MSc, MPH  ·  +33 630 842 002  ·  caroline.chevalier@ose-immuno.com

Bérangère Vasseur, MD  ·  +33 676 448 160  ·  berangere.vasseur@ose-immuno.com

Always discuss trial participation with your own doctor first.

Locations (207)

Clinical Research Advisors, LLCBeverly Hills, California, United StatesRecruiting
Clinical Research Advisors - EncinoEncino, California, United StatesActive Not Recruiting
Clinical Research Advisors - West HollywoodLos Angeles, California, United StatesActive Not Recruiting
Clinical Research Advisors - Korea TownLos Angeles, California, United StatesActive Not Recruiting
SCL Health - Saint Joseph Hospital Cancer CenterLittleton, Colorado, United StatesWithdrawn
Lutheran Medical Center - Cancer Centers of ColoradoWheat Ridge, Colorado, United StatesRecruiting
Eastern Connecticut Hematology and Oncology AssociatesNorwich, Connecticut, United StatesRecruiting
Georgetown Lombardi Comprehensive Cancer CenterWashington D.C., District of Columbia, United StatesRecruiting
Comprehensive Hematology Oncology - Bradenton ClinicBradenton, Florida, United StatesActive Not Recruiting
Comprehensive Hematology Oncology - Brandon ClinicBrandon, Florida, United StatesActive Not Recruiting
Cancer Specialists of North Florida - Fleming IslandFleming Island, Florida, United StatesRecruiting
Cancer Specialists of North Florida - RiversideJacksonville, Florida, United StatesRecruiting

+ 195 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06472245