Condition: Hypoglycemia · Type 1 Diabetes · Sponsor: University of Cincinnati
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes. We have observed that the naturally occurring protein C-peptide increases glucagon secretion in dogs during insulin-induced hypoglycemia, which increases hepatic glucose production; the experiments in this application will shed light on the translation of this finding to the human.
This description comes directly from the study's public registry record.
Jason Winnick, PhD · 513-558-4437 · jason.winnick@uc.edu
Natalie Whitsett · 513-558-4489 · whitsenh@ucmail.uc.edu
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| University of Cincinnati | Cincinnati, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06470295