Condition: Atypical Teratoid/Rhabdoid Tumor · Embryonal Tumor With Multilayered Rosettes · Ewing Sarcoma · Sponsor: Milton S. Hershey Medical Center
The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authorities around the world for use alone or in combination with any drug, for the condition or illness it is being used to treat. The goals of this part of the study are: * Establish a recommended dose of AMXT 1501 in combination with DFMO * Test the safety and tolerability of AMXT 1501 in combination with DFMO * To determine the activity of study treatments chosen based on: * How each subject responds to the study treatment * How long a subject lives without their disease returning/progressing
This description comes directly from the study's public registry record.
BCC Enroll · 7175310003 · BCCEnroll@pennstatehealth.psu.edu
Always discuss trial participation with your own doctor first.
| University of Alabama/Children's of Alabama | Birmingham, Alabama, United States | Recruiting |
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | Recruiting |
| Connecticut Children's Hospital | Hartford, Connecticut, United States | Recruiting |
| Nicklaus Children's Hospital | Miami, Florida, United States | Recruiting |
| Arnold Palmer Hospital for Children | Orlando, Florida, United States | Recruiting |
| St. Joseph's Children's Hospital | Tampa, Florida, United States | Recruiting |
| Kapiolani Medical Center for Women and Children | Honolulu, Hawaii, United States | Recruiting |
| Children's Mercy Hospitals and Clinics | Kansas City, Kansas, United States | Recruiting |
| Cardinal Glennon Children's Medical Center | St Louis, Missouri, United States | Recruiting |
| Penn State Milton S. Hershey Medical Center and Children's Hospital | Hershey, Pennsylvania, United States | Recruiting |
| Monroe Carrell Jr. Children's Hospital at Vanderbilt | Nashville, Tennessee, United States | Recruiting |
| Children's Medical Center | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06465199