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Study identifier: NCT06464510 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis

Condition: Septic Shock  ·  Sponsor: Hospital do Coracao

PhasePhase 3
Planned participants2800
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The norepinephrine and vasopressin for rescue versus early vasopressin for vasopressor dependent sepsis (NoVa) is a phase 3, multicenter, open-label, randomized controlled trial comparing an early vasopressin initiation strategy versus norepinephrine plus vasopressin initiation only as a rescue strategy for hemodynamic management of critically ill patients with vasopressor dependent sepsis.

This description comes directly from the study's public registry record.

Talk to the study team

Bruno M Tomazini, MD  ·  +5511982839173  ·  btomazini@hcor.com.br

Alexandre Biasi Cavalcanti, PhD  ·  +551130536611  ·  abiasi@hcor.com.br

Always discuss trial participation with your own doctor first.

Locations (8)

Hospital Geral de Caxias do SulCaxias do Sul, Rio Grande do Sul, BrazilRecruiting
Hospital Nereu RamosFlorianópolis, Santa Catarina, BrazilRecruiting
Hospital SEPACOSão Paulo, S, BrazilNot Yet Recruiting
Hospital de Amor - Unidade Barretos (Fundação PIO XII)Barretos, São Paulo, BrazilNot Yet Recruiting
Hospital do CoracaoSão Paulo, São Paulo, BrazilRecruiting
BP-A Beneficiência Portuguesa de São PauloSão Paulo, São Paulo, BrazilNot Yet Recruiting
Hospital Alemão Oswaldo CruzSão Paulo, São Paulo, BrazilNot Yet Recruiting
Hospital São Paulo - UNIFESPSão Paulo, São Paulo, BrazilRecruiting

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Source record: clinicaltrials.gov/study/NCT06464510