Condition: Chordoma of Spine · Chordoma of Skull Base · Chordoma of Sacrum · Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
In this study the investigators will study the effects of neoadjuvant radiation therapy (RT), in the form of either proton therapy or stereotactic body radiation therapy (SBRT), on the Circulating tumor DNA (ctDNA), radiographic changes and radiomics, and the validity of these findings will be compared using the current gold standard- pathologic findings. The purpose of this work is to explore whether the biomarkers may be used diagnostically to better understand radiographic changes following RT. The investigators hypothesize that ctDNA levels in combination with imaging biomarkers identified through radiomics will be a sensitive and specific tool for predicting histopathologic response to RT.
This description comes directly from the study's public registry record.
Kristin Redmond, MD, MPH · 4106141642 · kjanson3@jhmi.edu
Jasmine Brooks, BA · 6673068335 · jbrook54@jhmi.edu
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| Johns Hopkins Hospital | Baltimore, Maryland, United States | Recruiting |
| University of Pennsylvania | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06463262