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Study identifier: NCT06462963 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)

Condition: Breast Cancer · Prostate Cancer · NSCLC  ·  Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

PhaseNA
Planned participants302
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate single-fraction metastases-directed SBRT in the broader radiation oncology community and to compare its safety and efficacy profile with the current Standard of Care (SoC) of multiple-fraction SBRT in patients with oligometastatic disease of primary breast, prostate, NSCLC and colorectal cancer having all lesions that will be treated with radical radiotherapy amenable to single-fraction SBRT. The main question/hypothesis this clinical trial aims to answer is: \- Single-fraction SBRT has comparable outcomes as those obtained with multiple fraction SBRT, both in terms of safety and efficacy. Patients from the OligoCare cohort will be randomized to receive either single-fraction SBRT or the current SoC of multiple-fraction SBRT.

This description comes directly from the study's public registry record.

Talk to the study team

EORTC HQ  ·  +32 2 774 16 11  ·  eortc@eortc.org

Always discuss trial participation with your own doctor first.

Locations (15)

Onze Lieve Vrouw ZiekenhuisAalst, BelgiumNot Yet Recruiting
Institut Jules BordetBrussels, BelgiumNot Yet Recruiting
Universitair Ziekenhuis GentGhent, BelgiumNot Yet Recruiting
AZ Groeninge KortrijkKortrijk, BelgiumNot Yet Recruiting
Ziekenhuis aan de Stroom (ZAS) - ZAS AugustinusWilrijk, BelgiumNot Yet Recruiting
Azienda Ospedaliero-Universitaria CareggiFlorence, ItalyNot Yet Recruiting
Istituto Clinico HumanitasMilan, ItalyNot Yet Recruiting
Istituto Europeo di OncologiaMilan, ItalyNot Yet Recruiting
Sacro Cuore HospitalNegrar, ItalyNot Yet Recruiting
Policlinico Universitario Campus Bio-Medico- Oncology CenterRoma, ItalyNot Yet Recruiting
Universita Di TorinoTorino, ItalyNot Yet Recruiting
Radiotherapiegroep ArnhemDeventer, NetherlandsNot Yet Recruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06462963