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Study identifier: NCT06462196 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Condition: Behavioral Symptoms · Suicide · Self-Injurious Behavior  ·  Sponsor: National Institute of Mental Health (NIMH)

PhaseN/A
Planned participants500
Who can joinAll sexes, 18 Years to 120 Years
Healthy volunteersNo

About this study

Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments. In this study, researchers want to perform tests on people undergoing clinical care for mood disorders. The purpose is to understand the experience of receiving treatment for depression, bipolar disorder, and suicide risk. We also hope that this study will help us to predict which medications will improve thoughts of suicide. People 18 years or older who are receiving treatment for depression, bipolar disorder, or suicide risk may take part in this study. Participants must have also been enrolled in protocol 01-M-0254. This study will be conducted at the NIH Clinical Center in Bethesda, MD. The study typically lasts up to 12 weeks, but may last longer if a participant s treatment continues past that time. Participants will have weekly interviews and questionnaires while they are being treated for their mood disorder. Other tests are optional and include psychological testing, blood draws, sleep tests, and imaging scans. These will be done at the start and the end of research participation....

This description comes directly from the study's public registry record.

Talk to the study team

Kelly T Hurst, Ph.D.  ·  (877) 646-3644  ·  moodresearch@mail.nih.gov

Elizabeth D Ballard, Ph.D.  ·  (301) 435-9399  ·  elizabeth.ballard@nih.gov

Always discuss trial participation with your own doctor first.

Locations (1)

National Institutes of Health Clinical CenterBethesda, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06462196